Expert - Farmaso

Warning

THIS SECTION IS INTENDED FOR EXPERT MEDICAL STAFF. CONSULT YOUR DOCTOR IF YOU ARE NOT A SPECIALIZED MEDICAL STAFF.

Antimicrobial Events

What the Hypochlorous?

It was first described by Sir Davy in 1823, produced by Faraday in 1881 and used as antiseptic solution during World War I in 1914.

This physiological molecule is synthesized during the phagocytosis action of neutrophils, which play an important role in the defense mechanisms of living things. Activation of neutrophils produces reactive oxygen species [ROS] Hydrogen peroxide [HO] and myeloperoxidase enzyme is involved in the process to produce HYPOCHLOROUS in the presence of H2O2 Cl and H+.

■ 200 ppm ■ ORP ±900 mv ■ pH ≈7.1

PROTEIN SYNTHESIS

Oxidation of sulfhydryl enzymes
Oxidation of amino acids
Chlorination of amino acids
Inhibition of protein synthesis

ENVIRONMENTAL RELATIONSHIP

Intercellular material loss
Reduction in food intake
Reduction of oxygen uptake

ENERGY PRODUCTION

Oxidation of respiratory components (ROS)
Reduction in adenosine triphosphate production

DNA DAMAGE

Fracture in DNA
Suppression of DNA synthesis

In this study, Pseudomonas Aeruginosa cells were stained with fluorescence and subjected to hypochlorous under video microscope and it was determined how long it was killed. With its High Redox Potential (ORP), it removes electrons from atoms of microorganisms and acts on all vital parts of the cell wall structure and DNA, killing them in seconds.

1st sec

6th sec.

12th sec

Bacterias

Viruses

Fungals

Parasites

Proteus mirabilis*
Pseudomonas aeruginosa*
Serratia marcences*
Mycoplasmalar
Rhizobialar
Pasteurella pneumotropica
Salmonella enteritidis
Salmonella paratyphi A
Salmonella typhi
Shigella flexneri
Bacilluslar (sporlu ve sporsuz formlara)
Clostridiumlar (sporlu ve sporsuz)
Chryseobacterium Meningosepticum
Staphylococcus aureus*
Staphylococcus epidermidis*
Staphylococcus haemolyticus*
Staphylococcus hominis*
Staphylococcus saprophyticus*
Stenotrophomonas maltophilia
Streptococcus pneumoniae
Streptococcus pyogenes

Adenoviridealar: Adenovirus
Picarnoviridae: Coxakivirus
Herpersviridae: Ebstein-barr virus,
Herpes simplex tip 1, 2 ve 8,
Cytomegalovirus, Varicella Zoster
Hepadnaviridae: Hepatitis B virus
Flaviviridae: Hepatitis C virus
Retroviridae: HIV
Orthomyxoviridae: Influenza virus
Paramyxoviridae: Mumps, Measles
Respiratory Syncitial virus (Hrsv)
Papoviridea: Papillomavirus
Rhabdoviridea: Rotovirus
Togoviridae: Rubella Virus
Reoviridae: Rota Virus
Poliovirus
Parainfluenza
Hepatitis A virus

Aspergillus fumigatus
Aspergillus niger
Candida Albicans
Microsporum
Epidermophyton floccosum*
Rhizopus oryzae
Trichophyton rubrum*
Trichopyton tonsurans*
Trichophyton verrucosum*

Acanthamoeba spp.
Trichomonas vaginalis

Bacterias

Corynebacterium amycolatum*
Enterobacter aerogenes*
Actynomcesler
Chlamidialar
Bacteriodesler
Acinetobacter baumanii**
Bordetella bronchiseptica
Citrobacter freundii
Corynebacterium kutscheri
Enterecoccus feecium*
Escherichia coli*
Haemophilus influenzae*
Klebsiella pneumoniae*
Micrococcus luteus*
Mycobacteriumlar
Enterobacter cloacae
Enterococcus faecalis *
Klebsiella oxytoca**
Listonella anguillarum
Moraxella catarrhalis
Proteus mirabilis*
Pseudomonas aeruginosa*
Serratia marcences*
Mycoplasmalar
Rhizobialar
Pasteurella pneumotropica
Salmonella enteritidis
Salmonella paratyphi A
Salmonella typhi
Shigella flexneri
Bacilluslar (sporlu ve sporsuz formlara)
Clostridiumlar (sporlu ve sporsuz)
Chryseobacterium Meningosepticum
Staphylococcus aureus*
Staphylococcus epidermidis*
Staphylococcus haemolyticus*
Staphylococcus hominis*
Staphylococcus saprophyticus*
Stenotrophomonas maltophilia
Streptococcus pneumoniae
Streptococcus pyogenes

Viruses

Fungals

Aspergillus fumigatus
Aspergillus niger
Candida Albicans
Microsporum
Epidermophyton floccosum*
Rhizopus oryzae
Trichophyton rubrum*
Trichopyton tonsurans*
Trichophyton verrucosum*

Parasites

Acanthamoeba spp.
Trichomonas vaginalis

Biofilms Activity

It eradicates the biofilm layer formed by resistant microorganisms. It also kills microorganisms in dormant form under the biofilm.

Effects of Process Improvement Accelerator

According to the clinical study performed with Povidone iodine on fibroblasts and keratinocytes;

In addition to antimicrobial activity, it shortens the healing process by accelerating the migration of Fibroblast and Keratinocytes to the wound site, which are the two main cells responsible for tissue healing.

Effect on Fibroblasts

Effect on Keratinocyte

Indications

In all the following applications, when used as an adjunct to existing antibiotherapy, antibiotherapy reduces the amount and duration of use. Accelerates recovery.

Wound Care Applications

Treatment of diabetic foot wounds,
Back, hip, heel and so on developed for a long time. treatment of wounds,
Whatever the cause, treatment of acute and chronic wounds,
In the treatment of partial and complete skin injuries,
In the treatment of postoperative wounds,
Graft mesh, punch skin grafts and biopsies
Treatment of burns (1 degree to 2 degree)
Skin Ulcers (Stage I-IV)
Prevention and treatment of skin problems caused by bumps, scratches and cuts,
In the treatment of abscesses,
Wound irrigation and debridement (removal of dead tissues)
Moistening the wound and reducing its odors,

Non-Wound Applications

In the treatment of oral aphthae with virus or fungi,
Herpes Simplex virus is effective in the prevention and treatment of herpes problems
Treatment of bacterial and viral eye infections,
Eye and environment care,
Care of the ear and its surroundings,
Facial cleansing against acne and pimples

References

The inhibition of bacterial growth by hypochlorous acid.Possible role in the bactericidal activity of phagocytes - McKenna 1988
Susan M. McKENNA and Kelvin J. A. DAVIES
Hypochlorous Acid as a Potential Wound Care Agent – 2007
Wang L, PhD,a Bassiri M, PhD,a Najafi R, PhD,a Najafi K, MD,b Yang J, BS,a Khosrovi B, PhD,a Hwong W, BS,a Barati E, BS,a Belisle B, PhD,a Celeri C, MSa,and Robson MC, MDc
Fungal Infections Following Boston Type 1 Keratoprosthesis Implantation Literature Review and In Vitro Antifungal Activity of Hypochlorous-2015
Silvia Odorcic, MD, FRCSC, Wolfgang Haas, PhD, Michael S. Gilmore, PhD, and Claes H. Dohlman, MD, PhD
I-İslam I.Ragap -The Effectiveness of Hypochlorous Acid Solution on Healing of Infected Diabetic Foot Ulcers
Islam.I.Ragab1 Ahmed Kamal 2
Stabilised Hypoclorous acid A New Therapeutic Strategy Against Dangerous Parasitic Eye Infection Agent - Acanthamoeba spp.- 2018
I. YILDIZ, O. YILMAZ, E. TILEKLIOGLU, S. SAKARYA, H. ERTABAKLAR
The Role of Hypochlorous Acid in Managing Wounds
Martha Kelso
Clinical Outcomes of Wide Postsurgical Lesions in the Infected Diabetic Foot Managed With 2 Different Local Treatment Regimes Compared Using a Quasi-Experimental Study Design: A Preliminary Communication
Chiara Goretti, Sabrina Mazzurco, Laura Ambrosini Nobili, Silvia Macchiarini, Anna Tedeschi, Francesca Palumbo, Alessia Scatena, Loredana Rizzo, Alberto Piaggesi
Hypochlorous Acid Solution: A Tale Of Two Clinics A Safe Effective Alternative for Treating and Preventing Infection?
Kazu Suzuki DPM, CWS, Albemar Espirtu DPM, WCC
Hypochlorous Acid An Ideal Wound Care Agent With Powerful Microbicidal, Antibiofilm and Wound Healing Potency - 2014
Serhan Sakarya, MD1; Necati Gunay, MS2; Meltem, Karakulak, MS3; Barcin Ozturk, MD1; Bulent Ertugrul, MD1
Adjunctive Debridement with Hypoclorous acid Leads To A Healing Trajectory Of Complex Wounds In Children-2016
Ferne T. Elsass, MSN, RN, CPN, CWON; Clinical Practice and Education Specialist of Wound and Ostomy, Children’s Hospital of The King’s Daughters, Norfolk, VA 23507
Antimicrobial effect of hypochlorous acid on pathogenic microorganisms-2013-Korea
Sang Phil Shin1,*, Mun Sup Kim1,*, Sung Hee Cho2, Ji Hyung Kim1, Casiano H. Choresca Jr1, Jee Eun Han1, Jin Woo Jun1, Se Chang Park1,†
Antiseptik bazlı çözeltilerin İnsan Keratinosit Hücre Dizisi(Hacat) Proliferasyonuna etkilerinin karşılaştırılması - 2013
Arzu Onay Beşikçi, Tuğbay Tuğ
Disinfection of titanium dioxide nanotubes using super-oxidized water decrease bacterial viability without disrupting osteoblast behavior-2016
Ernesto Beltrán-Partida a,b, Benjamín Valdez-Salas b,⁎, Alan Escamilla b, Mario Curiel b, Ernesto Valdez-Salas c, Nicola Nedev b, JoseM. Bastidas
Effect of Electrolyzed Strong Acid Water on Peritoneal Irrigation of Experimental Perforated Peritonitis-2009 - Japan
Akio Kubota, Keisuke Nose, Takeo Yonekura, Takuya Kosumi, Katsuji Yamauchi and Harumasa Oyanagi
Expert Recommendations For The Use Of Hypoclorous Solution Science and clinical application - 2015
David G. Armstrong, DPM, MD, PhD, Gregory Bohn, MD, FACS, ABPM/UHM, FACHM, Paul Glat, MD, FACS, Steven J. Kavros, DPM, FACCWS,CWS, Robert Kirsner, MD, PhD, Robert Snyder, DPM, MSc, CWS, William Tettelbach, MD, FACP, CWS

Hypochlorous Acid - Analytical Methods and Antimicrobial Activity-2012-Ankara Üniversity
Müjde Eryılmaz and İsmail Murat Palabıyık
Hypochlorous acid is antipruritic and anti-inflammatory in a mouse model of atopic dermatitis -Fukuyama- 2017
T. Fukuyama, B. C. Martel, K. E. Linder, S. Ehling, J. R. Ganchingco, W. Baumer
Hypochlorous-Acid-Generating Electrochemical Scaffold for Treatment of Wound Biofilms-2019
Mia Mae Kiamco, Hannah M. Zmuda, Abdelrhman Mohamed, Douglas R. Call, Yash S . Raval, Robin Patel & Haluk Beyenal
Hypoclorous acid Demonstrates Antiviral Properties Against Herpes Simplex Virus - 2010
G.A. Denys, V. Dzyakanava, P. O’Hanley, and J.T. Stephens, Jr.
Improved Outcomes After Low-Concentration Hypochlorous Acid-The Laryngoscop-2015
Hyung-Ju Cho, MD, PhD; Hyun Jin Min, MD, PhD; Hyo Jin Chung, MD; Do-Yang Park, MD; Sang Yeob Seong, MD; Joo-Heon Yoon, MD, PhD; Jeung-Gweon Lee, MD, PhD; Chang-Hoon Kim, MD, PhD
In vitro microbicidal, anti-biofilm and cytotoxic effects of different commercial antiseptics-2017
Silvestre Ortega-Peña, Christian Hidalgo-González, Martin C Robson & Edgar Krötzsch
Inactivation of bacteria on surfaces by sprayed slightly acidic hypochlorous acid-Hakimullah Hakim-2016
Hakimullah HAKIM), Md. Shahin ALAM), Natthanan SANGSRIRATANAKUL), Katsuhiro NAKAJIMA), Minori KITAZAWA), Mari OTA), Chiharu TOYOFUKU), Masashi YAMADA), Chanathip thammakarn), Dany SHOHAM) and Kazuaki TAKEHARA
Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid - 2016-Canada
Andrew G. Hughson, Brent Race, Allison Kraus, Laura R. Sangare, Lori Robins, Bradley R. Groveman, Eri Saijo, Katie Phillips, Luis Contreras, Virkamal Dhaliwal,
Matteo Manca, Gianluigi Zanusso, Daniel Terry, Jeffrey F. Williams, Byron Caughey
International Wound Infection Institute (IWII) Wound infection in clinical practice. Wounds - International 2016 UPDATE
Terry Swanson
IWGDF guidance on the diagnosis and management of foot infections in persons with diabetes 2016 -Lipsky
Benjamin A. Lipsky, Javier Aragón-Sánchez, Mathew Diggle, John Embil, Shigeo Kono, Lawrence Lavery, Éric Senneville, Vilma Urbančič-Rovan, Suzanne Van Asten, Edgar J. G. Peters
Low-concentration hypochlorous acid nasal irrigation for chronic sinonasal symptoms a prospective randomized placebo-controlled study-2017
Yu MS, Kim BH, Kang SH, Lim DJ
Topical Hypochlorous Acid (HOCl) as a Potential Treatment of Pruritus 2013
Robert Y. Pelgrift
Universal decolonization with hypochlorous solution in a burn intensive care unit in a tertiary care community hospital 2016
Gray D, Foster K, Cruz A, Kane G, Toomey M, Bay C, Kardos P, Ostovar GA
Use of Hypochlorous Acid Solution as a Disinfectant in Laboratory Animal Facilities-2015
Kazuo Goto, Kaga, Itabashi-ku
Hypoclorous acid Irrigation in Reducing Infection of a Median Sternotomy Wound-2010
Abdul Ramzisham Rahman Mohd, MS, Mohd Khairulasri Ghani, MD, Rafl is Ruzairee Awang, MBChB, Joanna Ooi Su Min, MMed, Mohd Zamrin Dimon, MS
Effects of Hypochlorous Acid Solutions on Venous Leg Ulcers (VLU) Experience With 1249 VLUs in 897 Patients -2016
Cheryl M. Bongiovanni, PhD, RVT, CWS, FASA, FACCWS

Viruses

Fungals

Aspergillus fumigatus
Aspergillus niger
Candida Albicans
Microsporum
Epidermophyton floccosum*
Rhizopus oryzae
Trichophyton rubrum*
Trichopyton tonsurans*
Trichophyton verrucosum*

Acanthamoeba spp.
Trichomonas vaginalis